CBD Oil for Arthritis: Benefits & How to Use for Rheumatoid Arthritis

Living with rheumatoid arthritis means that you’re somewhat cursed to live with chronic pain and treat pain management as a regular part of daily life.

Sometimes, the pain is manageable on its own, but the worst part of having arthritis is the flare-ups that can be debilitating for severe arthritis sufferers.

Many people diagnosed with arthritis use prescription medications that relieve pain and lessen inflammation, but the problem is they also entail a very long list of unpleasant side effects.

For this reason, natural solutions are a popular choice for managing the two symptoms caused by arthritis. Among those natural products, cannabidiol is a term that you might hear about time and again.

Cannabidiol is more commonly known as CBD — it’s a powerful, non-intoxicating compound found in cannabis plants. Most often, people use it in oil form under their tongue.

In recent years, CBD has been hyped as the next big solution for everything — from childhood epilepsy to anxiety, chronic pain, nausea, and so much more.

But is CBD oil effective for arthritis symptoms?

I’ll give you the answer in this article — along with two brands that, in my opinion, manufacture the best CBD oil on the market as of this writing.

Best CBD Oils for Arthritis

If you’ve been considering trying CBD oil for your arthritis symptoms, you’ve been probably stricken by the overwhelming number of manufacturers.

It’s important to source your CBD oil from companies that use organic hemp plants and employ butane-free extraction methods. They should also post lab reports for each product on their website to ensure you’re buying clean, potent, high-quality CBD oil.

That being said, I trust the products from these two brands enough to recommend them to anyone looking for improvements in their quality of life.

1. Royal CBD

Royal CBD 1000mg oil bottle


  • Royal CBD uses organic hemp grown in Colorado
  • Their products are extracted with supercritical CO2
  • The company offers both full-spectrum and “zero-THC” products
  • The CBD oil is suspended in premium MCT oil
  • Very potent — up to 33.3 mg of CBD per mL
  • Every batch of product has been tested by a third-party laboratories


  • No topicals available yet
  • These products are priced on the higher end, although well justified

See Lowest Price

My Thoughts on Royal CBD:

A newcomer to the scene, Royal CBD is a premium manufacturer that uses only high-quality ingredients in their CBD line. The company’s product range is pretty simple, featuring only CBD oil, capsules, and gummies.

The oil and capsules are full-spectrum while the gummies are made out of 99% pure CBD isolate. What I like about the Royal CBD oil is the potency it offers. The strongest option carries 33.3mg of CBD in each milliliter, which is great if you need high doses of CBD in your life.

If you don’t like the taste of natural CBD oil, you can get their capsules instead. These come in an easy-to-swallow softgel form and contain 25mg per capsule.

All Royal CBD products are tested in third-party laboratories to ensure that each batch is clean and have consistent levels of CBD.

2. CBDPure

CBDPure Oil Bottles


  • CBDPure products are sourced from organic hemp grown in Colorado
  • The company uses CO2 to make its extracts
  • All products are tested by 3rd-party laboratories for potency and purity
  • 100% Satisfaction Guaranteed program (full refund within 90 days)


  • Narrow product range
  • The oil is slightly less potent than Royal CBD

My Thoughts on CBDPure:

Founded in 2016 by cannabis aficionados from Colorado, CBDPure has a simple mission — to make high-quality CBD oils made from organic hemp.

Although the company only sells CBD oil and capsules, it has perfected both of these products. These extracts are made with supercritical CO2 and tested in third-party laboratories for quality assurance.

When it comes to their CBD oil, it isn’t as potent as the one offered by Royal CBD, so you may use it for a general health boost or alleviate mild symptoms. If you want something more potent, you may go for their softgels — each capsule is infused with 25mg of full-spectrum CBD.

In case you ended up unsatisfied with your product, CBDPure will give you a full refund if you send your order back within 90 days as part of their 100% Satisfaction Guaranteed program.

What is Arthritis?

Arthritis is one of the most common causes of disability in the United States. According to the Arthritis Foundation, it affects over 50 million Americans.

The disease causes severe inflammation and pain, as well as swelling and loss of function in the joints.

There are two common types of arthritis:

  • Rheumatoid arthritis: an autoimmune condition in which a person’s immune system attacks their joints, causing inflammation. This form of arthritis typically affects the hands and feet, causing pain and stiffness in the joints.
  • Osteoarthritis: a degenerative illness that causes pain and stiffness in joint cartilage and bones. It often attacks the hip, knee, and thumb joints.

Cannabinoids, such as CBD, are known for their analgesic properties. They engage with the endocannabinoid system to mitigate pain signaling and boosting immune function to reduce inflammation.

In other words, CBD affects the two main areas impacted by arthritis, hence its potential to relieve the symptoms.

How Can CBD Oil Help With Arthritis?

CBD oil is a high-CBD hemp extract, most often administered sublingually in the form of drops.

When CBD enters your bloodstream, it interacts with the endocannabinoid system — a complex neurochemical network responsible for maintaining every homeostatic function in the body. This includes pain perception, immune response, temperature control, memory, mood, hunger, fertility, and more.

Scientists believe that when CBD enters a person’s body, it modulates the cannabinoid receptors in the endocannabinoid system to reduce inflammation and pain.

While research on CBD and arthritis is in the early stage, current evidence coming from animal studies and several human trials suggests it may alleviate the symptoms of arthritis without causing any negative side effects.

Animal Studies on CBD & Arthritis

Some studies on animal models suggest that CBD could assist patients in treating arthritis and associated inflammatory pain.

  • A 2011 study discovered that CBD helped to curb inflammatory pain in rats by changing the way pain receptors react to stimuli.
  • A 2014 review of the existing animal-based studies concluded that CBD can be effective for relieving Osteoarthritis
  • In a 2016 study, researchers found that CBD may relieve inflammation linked to arthritis in problematic areas when applied topically.
  • A 2017 research paper suggested that CBD might be effective, and most importantly, safe treatment option for osteoarthritis joint pain.

Do human studies confirm what the above studies have found?

Evidence from Human Trials

In 2006, the first study on cannabinoids and rheumatoid arthritis concluded that a pharmaceutical CBD-enriched cannabis extract called Sativex had a “significant analgesic effect” on arthritis patients and that pain and inflammation were significantly reduced during the treatment. The study only found mild or moderate adverse effects but without negative withdrawal symptoms.

A 2008 study on cannabinoids in the management of chronic pain discovered that CBD effectively relieved pain and improved sleep quality in subjects.

Last but not least, a 2016 analysis of human trials for rheumatoid arthritis, osteoarthritis, and fibromyalgia also found that CBD improved pain and sleep patterns, although those studies were conducted on small samples — some scientists could argue their size was “methodologically insignificant.”

Where to Find CBD Oil for Arthritis for Sale

The majority of CBD stuff is sold online, which is also how I shop for CBD. Don’t get me wrong, it’s possible to find high-quality CBD oil in a local dispensary, but this option has a few downsides.

For one, dispensary owners often sell CBD oil at 3 x the price you would pay for the same product ordered online. Moreover, dispensaries don’t always have the best products, and most of them have been kept on the shelves for weeks after their delivery.

This isn’t a problem with online stores. The Internet gives you access to a wide range of different CBD products, including premium brands. You can easily check the credibility of your potential vendor by reading testimonies from their customers and checking the lab reports of their products.

Must-Know Details for People Buying CBD Oil for Arthritis

Knowing what to look for in the best CBD oil for arthritis will save you lots of stress and hassle — both before and after the purchase.

CBD is an emerging market, so it’s no wonder many companies want to capitalize on the booming trend before the dust settles.

With such an abundance of different brands selling CBD in various forms, it’s important to find a trusted manufacturer who will ensure high standards for their products.

Here’s what you should pay attention to when buying CBD oil for arthritis.

1. Hemp Source

Hemp will absorb literally everything from the soil it grows in because it’s a bioaccumulator. With that said, it’s important that your vendor uses CBD extracts that are sourced from organic, preferably American-grown hemp. US farmers have high standards for growing hemp plants and are subject to stricter regulations than growers in other countries.

2. Extraction Method

Most reputable companies use CO2 for making their CBD oil. Pressurized CO2 works as a solvent that pulls CBD and other compounds from the plant material, leaving behind clean and potent extracts.

3. Cannabinoid Spectrum

Experts argue that full-spectrum CBD oil is better for arthritis-related inflammation. A 2016 Israeli study found that unlike pure CBD, full-spectrum extracts may help the user overcome the bell-shaped dose-response — when a compound loses efficacy upon increasing the dose — which extends its clinical use.

4. Route of Administration

CBD comes in a few different forms. Commonly used products include:

  • Sublingual drops
  • Edibles
  • Vape liquids
  • Topicals

Sublingual drops and vape oils are the best types of CBD oil you can use for arthritis. They both guarantee fast absorption and high bioavailability. Bioavailability is measured by the amount of CBD that reaches the bloodstream.

For localized inflammation and pain, you can use topical CBD products such as creams, balms, and ointments.

5. Third-party Testing

Every company has the option to send a batch of their product to a third-party laboratory for content analysis. These laboratories measure the potency of CBD, scan the entire cannabinoid profile of the product, and can detect over 200 common contaminants.

If a company tests its products in third-party labs, it means they care about the safety of their customers. And it posts the lab reports on its website — it’s all the better.

What’s the Ideal CBD Dosage for Arthritis?

There is actually no one-size-fits-all dosage of cannabidiol when it comes to inflammatory pain caused by arthritis. However, information gathered from CBD users suggests that arthritis sufferers should take 25mg of CBD twice a day for a starting point — and observe the effects over a week-long period.

If you don’t feel any difference, gradually increase the amount of CBD oil until you find the effective dose.

Final Thoughts on Using CBD Oil for Arthritis

So far, research investigating the benefits of CBD oil for arthritis shows promising results.

Although a large share of the studies comes from animal models, there are ongoing human trials that are also positive about the potential of CBD to relieve inflammation and pain associated with arthritis.

Nevertheless, remember that CBD isn’t an overnight fix to all your problems, and in more serious cases, it may need some time to make the difference in your functioning. If you’re planning to use CBD oil for arthritis, consult your doctor to see if supplementation with CBD is right for you.


  1. Schuelert, N. & Mcdougall, J.J. (2011). the Abnormal Cannabidiol Analogue O-1602 Reduces Nociception in a Rat Model of Acute Arthritis Via the Putative Cannabinoid Receptor Gpr55., Neuroscience Letters, 500(1), 72–76.
  2. La Porta, C., Bura, S.A., Negrete, R., Maldonado, R. (2014). Involvement of the Endocannabinoid System in Osteoarthritis Pain. The European Journal of Neuroscience, 39(3), 485–500.
  3. Philippot, H.T., O’Brien, M., McDougall, J.J. (2017). Attenuation of Early Phase Inflammation By Cannabidiol Prevents Pain and Nerve Damage in Rat Osteoarthritis. Pain, 158(12), 2442–2451.
  4. Blake, D.R., Robson, P., Ho, M., Jubb, R.W., McCabe, C.S. (2006) Preliminary Assessment of the Efficacy, Tolerability and Safety of a Cannabis-based Medicine (Sativex) in the Treatment of Pain Caused by Rheumatoid Arthritis. Rheumatology (Oxford), 45(1), 50–52.
  5. Russo E. B. (2008). Cannabinoids in the Management of Difficult to Treat Pain. Therapeutics and Clinical Risk Management, 4(1), 245–259.
  6. Fitzcharles, M.A., Baerwald, C., Ablin, J., Hauser, W. (2016). Efficacy, Tolerability and Safety of Cannabinoids in Chronic Pain Associated With Rheumatic Diseases (fibromyalgia Syndrome, Back Pain, Osteoarthritis, Rheumatoid Arthritis): a Systematic Review of Randomized Controlled Trials. Schmerz (Berlin, Germany), 30(1), 47–61.
  7. Gallily, R., Yekhtin, Z., Lumir, O.H. (2015). Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol. Pharmacology & Pharmacy, 6, 75–85.

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